Abstract
Background: Autism spectrum disorder (ASD) in children often involves deficits in communication, social interaction, and behavioral regulation. Emerging evidence suggests that vitamin B6 and magnesium supplementation may aid in alleviating these symptoms. This study aims to assess the effectiveness of vitamin B6 plus magnesium in improving social, nonverbal communication, speech, and language skills in preschool children with ASD and well-controlled epilepsy.
Methods: A double-blind placebo-controlled trial was conducted involving 50 children under 14 years diagnosed with ASD based on CARS-2 criteria. Participants were randomly assigned to either receive vitamin B6 plus magnesium (n=25) or a placebo (n=25) for 120 days. Clinical outcomes were evaluated weekly and analyzed using SPSS v19.
Results: The intervention group showed significant improvement in social skills (Mean = 11.10, SD = 0.47, p = 0.0103), nonverbal communication (Mean = 10.67, SD = 0.59, p = 0.0024), and speech and language skills (Mean = 10.87, SD = 0.47, p = 0.0030) compared to the placebo group.
Conclusion: Vitamin B6 plus magnesium significantly improves cognitive and language functions in children with ASD and well-controlled epilepsy.
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References
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